THE VITAMIN B12 AND FOLATE PATHOLOGY INVESTIGATION
THE INVESTIGATION OF ERRORS IN PATHOLOGY TESTS
FOR VITAMIN B12 AND FOLATE DEFICIENCY
BY MEANS OF MEDICAL EXPERIMENTS
THE HOMOCYSTEINE INVESTIGATION
THE HCY EXPERIMENT
Summary
Method
Observations
Results - Notes
Results - Series 1
SNP vs CHW
Results - Series 1b
Conclusions

The important points to note, about homocysteine levels, from the SNP Sample A and Westmead Sample A results are:

  • The maximum difference between the labs was 8.71 SD.
  • All 15 results were outside the 95% Confidence Interval.
  • 13 of those results were also outside the 99.0% Confidence Interval.
  • All 13 of those results were also outside the 99.9% Confidence Interval.
Chart E12 Table B18

The important points to note, about homocysteine levels, from the SNP Sample B and Westmead Sample B results are:

  • The maximum difference between the labs was 10.30 SD.
  • 15 out of 16 results were outside the 95% Confidence Interval.
  • All 15 of those results were also outside the 99.0% Confidence Interval.
  • All 15 of those results were also outside the 99.9% Confidence Interval.
Chart E13 Table B18

The Westmead results for homocysteine were significantly more consistent with the relationship between homocysteine and serum B12, as reported by Refsum et al, reference AE11 Figure 7, than were the SNP results.

The important points to note are:

  • All of the SNP homocysteine results were significantly lower than would be expected from the findings of Refsum.
  • The Westmead homocysteine results are generally very close to those predicted by Refsum.
  • The Westmead results that are significantly higher than the Refsum curve, shown as points B, were recorded at a time of rapid change in cellular deficiency, as defined by the rapidly increasing MMA levels. During a time of such rapid change, because of differences in analyte response times, the relationship between them is temporarily affected.
  • The result at point A is the B12 anomaly of 9 October 2006.
Chart C31 Table C9

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