THE VITAMIN B12 AND FOLATE PATHOLOGY INVESTIGATION
THE INVESTIGATION OF ERRORS IN PATHOLOGY TESTS
FOR VITAMIN B12 AND FOLATE DEFICIENCY
BY MEANS OF MEDICAL EXPERIMENTS
THE SERUM VITAMIN B12 INVESTIGATION
THE SERUM B12 EXPERIMENT - A
Summary
Method
Observations
Results - Notes
Results - Assay Quality
Results - Analyte Utility
Serum B12 vs SNP HCY
Conclusions

The important points to note, about response of serum B12, from these SNP results are:

  • Initially borderline low quoted by SNP
  • Increased rapidly after commencing oral B12 on 2 November 2005
  • Fell rapidly to 323 pmol/L, after ceasing oral B12 on 10 February 2006
  • Continued to fall at much slower rate
  • Never fell below SNP normal range
  • Increased rapidly after re-commencing oral B12 on 13 November 2006

The important points to note, about response of homocysteine, from these SNP results are:

  • Initially 11.9, then 12.3 umol/L, well below maximum limit quoted by SNP.
  • Fell rapidly after commencing oral B12 on 2 November 2005, reaching minimum of 7.0 umol/L.
  • Increased again, remaining within the range 7.9 to 9.2 umol/L for several months.
  • Never exceeded the normal range quoted by SNP.
  • Fell rapidly after re-commencing oral B12 on 13 November 2006
Chart C25
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