REFERENCES AND LINKS

THE VITAMIN B12 AND FOLATE PATHOLOGY INVESTIGATION

THE INVESTIGATION OF ERRORS IN PATHOLOGY TESTS

FOR VITAMIN B12 AND FOLATE DEFICIENCY

BY MEANS OF MEDICAL EXPERIMENTS

INTRODUCTION	THE SERUM VITAMIN B12 INVESTIGATION	THE METHYLMALONIC ACID INVESTIGATION
THE HOMOCYSTEINE INVESTIGATION	THE HOLOTRANSCOBALAMIN INVESTIGATION	THE FOLATE INVESTIGATION
REFERENCES AND LINKS	B12 AND FOLATE INFORMATION	RESPONSES TO INVESTIGATION

VITAMIN B12 REFERENCES

FOLATE REFERENCES

VITAMIN B12 LINKS

FOLATE LINKS

Folate References

Part A - Errors - Folate

Part B - Errors - General

Part C - Experimental

Part D - Development

Part E - Non-Dietary

Part F - Dietary Deficiency

Part G - Consequences

Part H - Diagnosis

Part I - General

Index

This page contains the following sections:

D - Development of Folate Deficiency

DA - Stages in Development of Folate Deficiency
DB - Folate Metabolism
DC - Folate and Red-Cell Life Cycle

You can go to a section by selecting the link.

DA - Stages in Development of Folate Deficiency

Number	Article Link
DA01	The 1986 Herman award lecture. Nutrition science as a continually unfolding story: the folate and vitamin B-12 paradigm, Victor Herbert, Am J Clin Nutr. 1987 Sep;46(3):387-402.

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DB - Folate Metabolism

Number	Article Link
DB01	A human model to determine folate bioavailability from food: a pilot study for evaluation, Cornelia M. Witthöft et al, Food & Nutrition Research, Vol 47, No 1 (2003)
DB02	A Mathematical Model of the Folate Cycle NEW INSIGHTS INTO FOLATE HOMEOSTASIS, H. Frederik Nijhout et al, The Journal of Biological Chemistry, 279, 55008-55016, December 31, 2004
DB03	A study of folate absorption and metabolism in man utilizing carbon-14—labeled polyglutamates synthesized by the solid phase method, C. E. Butterworth, Jr. et al, J Clin Invest. 1969;48(6):1131–1142
DB04	Availability of Food Folate in Humans, Reinhild Prinz-Langenohl et al, Journal of Nutrition. 1999;129:913-916
DB05	Case Study: Folate Bioavailability, Jesse F. Gregory, III, Journal of Nutrition. 2001;131:1376S-1382S.)
DB06	Case Study: Folate Bioavailability, Jesse F. Gregory, Food Science & Human Nutrition Dept., University of Florida
DB07	Folate bioavailability: UK Food Standards Agency workshop report, Peter Sanderson et al, British Journal of Nutrition (2003), 90, 473–479
DB08	Folate Metabolism and Requirements, Lynn B. Bailey and Jesse F. Gregory, III, Journal of Nutrition. 1999;129:779-782
DB09	In vivo folate kinetics during chronic supplementation of human subjects with deuterium-labeled folic acid, von der Porten AE et al, J Nutr. 1992 Jun;122(6):1293-99.
DB10	Kinetic Model of Folate Metabolism in Nonpregnant Women Consuming [2H2]Folic Acid: Isotopic Labeling of Urinary Folate and the Catabolite para-Acetamidobenzoylglutamate Indicates Slow, Intake-Dependent, Turnover of Folate Pools, Jesse F. Gregory III et al, J. Nutr. November 1, 1998 vol. 128 no. 11 1896-1906
DB11	Kinetic modeling of folate metabolism through use of chronic administration of deuterium-labeled folic acid in men, TE Stites et al, Am J Clin Nutr January 1997 vol. 65 no. 1 53-60
DB12	Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects, Henk J. Blom and Yvo Smulders, J Inherit Metab Dis. 2011 February; 34(1): 75–81.
DB13	Quantifying human vitamin kinetics using AMS, J.S. Vogel et al, UCRL-CONF-202463, Lawrence Livermore National Laboratory
DB14	Quantitation of in vivo human folate metabolism, Yumei Lin et al, Am J Clin Nutr September 2004 vol. 80 no. 3 680-691
DB15	Study on circadian variation in folate pharmacokinetics, Eric Ahn et al, Can J Clin Pharmacol Vol 12(1) Winter 2005:e4-e9; Jan. 7, 2005
DB16	Physiology of folic acid in health and disease, Stanger O, Current Drug Metabolism [2002, 3(2):211-23]
DB17	Kinetic Model of Folate Metabolism in Nonpregnant Women Consuming [2H2]Folic Acid: Isotopic Labeling of Urinary Folate and the Catabolite para-Acetamidobenzoylglutamate Indicates Slow, Intake-Dependent, Turnover of Folate Pools, Jesse F. Gregory III et al, J. Nutr. November 1, 1998 vol. 128 no. 11 1896-1906
DB18	Predicted serum folate concentrations based on in vitro studies and kinetic modeling are consistent with measured folate concentrations in humans., Miriam Verwei et al, J. Nutr. December 1, 2006 vol. 136 no. 12 3074-3078
DB19	A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism., Michael C. Reed et al, J. Nutr. October 1, 2006 vol. 136 no. 10 2653-2661
DB20	Differential Kinetic Behavior and Distribution for Pteroylglutamic Acid and Reduced Folates: a Revised Hypothesis of the Primary Site of PteGlu Metabolism in Humans, Anthony J. A. Wright et al, J. Nutr. March 1, 2005 vol. 135 no. 3 619-623
DB21	Single oral doses of 13C forms of pteroylmonoglutamic acid and 5-formyltetrahydrofolic acid elicit differences in short-term kinetics of labelled and unlabelled folates in plasma: potential problems in interpretation of folate bioavailability studies, A. J. A. Wright et al, Br J Nutr. 2003 Aug;90(2):363-71.
DB22	Folic acid metabolism in human subjects revisited: potential implications for proposed mandatory folic acid fortification in the UK., Anthony J. A. Wrighta, Jack R. Daintya and Paul M. Finglasa, Br J Nutr. 2007 Oct;98(4):667-75. Epub 2007 Jul 9
DB23	Intestinal absorption of different types of folate in healthy subjects with an ileostomy, Erik J. M. Konings et al, Br J Nutr. 2002 Sep;88(3):235-42.
DB24	A Dual-Label Stable-Isotopic Protocol Is Suitable for Determination of Folate Bioavailability in Humans: Evaluation of Urinary Excretion and Plasma Folate Kinetics of Intravenous and Oral Doses of [13C5] and [2H2]Folic Acid, Lisa M. Rogers et al, J. Nutr. December 1, 1997 vol. 127 no. 12 2321-2327

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DC - Folate and Red-Cell Life Cycle

Number	Article Link
DC01	THE LIFE SPAN OF THE HUMAN RED BLOOD CELL, DAVID SHEMIN AND D. RITTENBERG, J. Biol. Chem., 166, 621 (1946).
DC02	The measurement and importance of red cell survival, Robert S. Franco, Am J Hematol. 2009 Feb;84(2):109-14.
DC03	A detailed study of time-dependent changes in human red blood cells: from reticulocyte maturation to erythrocyte senescence, Sean C. Gifford et al, Br J Haematol. 2006 Nov;135(3):395-404. Epub 2006 Sep 21
DC04	THE USE OF RADIOACTIVE CHROMIUM 51 AS AN ERYTHROCYTE TAGGING AGENT FOR THE DETERMINATION OF RED CELL SURVIVAL IN VIVO, Franklin G. Ebaugh et al, J Clin Invest. 1953 December; 32(12): 1260–1276.
DC05	Measurement of red cell survival using biotin-labeled red cells: validation against 51Cr-labeled red cells, Donald M. Mock et al, Transfusion Volume 39, Issue 2, pages 156–162, February 1999 Abstract free, full article requires payment
DC06	Reference values for red cell survival times., Lötter MG et al, J Nucl Med. 1991 Dec;32(12):2245-8.
DC07	Evaluation of Recommended Methods for Radioisotope Red Cell Survival Studies, TATSUMI UCHIDA, et al, The Tohoku Journal of Experimental Medicine Vol.120 , No.3(1976)pp.219-223
DC08	HEME SYNTHESIS AND RED BLOOD CELL DYNAMICS IN NORMAL HUMANS AND IN SUBJECTS WITH POLYCYTHEMIA VERA, SICKLE-CELL ANEMIA, AND PERNICIOUS ANEMIA, IRVING M. LONDON et al, The Journal of Biological Chemistry, 179, 463-484.
DC09	Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c, Robert M Cohen et al, Blood November 15, 2008 vol. 112 no. 10 4284-4291
DC10	Estimation of red blood cell lifespan from alveolar carbon monoxide measurements, Sheeja M. Krishnan and Narendra M. Dixit, Translational Research Volume 154, Issue 1 , Pages 15-17, July 2009 abstract free, full article requires payment
DC11	Simplification of the end-alveolar carbon monoxide technique to assess erythrocyte survival, Julie K Furne et al, The Journal of Laboratory and Clinical Medicine, Volume 142, Issue 1 , Pages 52-57, July 2003 abstract free, full article requires payment
DC12	Use of alveolar carbon monoxide to measure the effect of ribavirin on red blood cell survival, Mark A. Virtue et al, American Journal of Hematology, 76: 107–113.
DC13	Use of breath carbon monoxide measurements to assess erythrocyte survival in subjects with chronic diseases, Benjamin L. Mitlyng et al, American Journal of Hematology, 81: 432–438.
DC14	Relationship Between GHb Concentration and Erythrocyte Survival Determined From Breath Carbon Monoxide Concentration, Mark A. Virtue et al, Diabetes Care April 2004 vol. 27 no. 4 931-935

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