THE SERUM VITAMIN B12 INVESTIGATION

THE VITAMIN B12 AND FOLATE PATHOLOGY INVESTIGATION

THE INVESTIGATION OF ERRORS IN PATHOLOGY TESTS

FOR VITAMIN B12 AND FOLATE DEFICIENCY

BY MEANS OF MEDICAL EXPERIMENTS

INTRODUCTION	THE SERUM VITAMIN B12 INVESTIGATION	THE METHYLMALONIC ACID INVESTIGATION
THE HOMOCYSTEINE INVESTIGATION	THE HOLOTRANSCOBALAMIN INVESTIGATION	THE FOLATE INVESTIGATION
REFERENCES AND LINKS	B12 AND FOLATE INFORMATION	RESPONSES TO INVESTIGATION

THE SERUM B12 EXPERIMENT - A

Summary

Method

Observations

Results - Notes

Results - Assay Quality

Results - Analyte Utility

Serum B12 Response

Conclusions

The important points to note, about response of serum B12 levels, from these SNP results are:

Initially 100 pmol/L, borderline low quoted by SNP
Increased rapidly after commencing oral B12 on 2 November 2005, reaching peak of 1232 pmol/L
Fell spontaneously to 1099 pmol/L on 10 February 2006
Continued to fall rapidly to 323 pmol/L, after ceasing oral B12 on 10 February 2006
Continued to fall at much slower rate
Anomaly of 250 pmol/L on 9 October 2006
Increased rapidly after re-commencing oral B12 on 13 November 2006