THE VITAMIN B12 AND FOLATE PATHOLOGY INVESTIGATION
THE INVESTIGATION OF ERRORS IN PATHOLOGY TESTS
FOR VITAMIN B12 AND FOLATE DEFICIENCY
BY MEANS OF MEDICAL EXPERIMENTS
THE SERUM VITAMIN B12 INVESTIGATION
THE SERUM B12 EXPERIMENT - A
Summary
Analytes and Laboratories
Objectives
Findings
Method
Analysis - CI
Analysis - Pxu
Analysis - Pab
Observations
Problems
Lab Performance
Results - Notes
Notes for Charts and Tables
Results - Assay Quality
Serum B12 Anomaly
Results - Analyte Utility
Serum B12 vs MMA
Serum B12 vs SNP HCY
Conclusions
Diagnositic Utility

Test Series

The following series of pathology tests was used for THE SERUM B12 EXPERIMENT PART A :

  • Series 1 - Serum B12 Investigation

Analytes

The following tests were compared for effectiveness as tests for vitamin B12 deficiency:

  • Total Serum vitamin B12
  • Total Homocysteine
  • Methylmalonic Acid

Laboratories

  • Sullivan Nicolaides Pathology, Brisbane (SNP)
  • NSW Biochemical Genetics Service, Children's Hospital Westmead, Sydney (CHW)

Duration

  • 24 October 2005 to 27 November 2006

Number of Tests

  • 39 blood sample collections
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